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Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y
T cells efficiently respond to foreign antigens to mediate immune responses against infections butDefect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potentialThis review will discuss the recent progresses regarding the functions of DUBs in T cells.
Keywords: deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z
Keywords: CAR T cells hematological malignancies review
Regulation of T cell immunity by cellular metabolism
Zhilin Hu, Qiang Zou, Bing Su
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 463-472 doi: 10.1007/s11684-018-0668-2
T cells are an important adaptive immune response arm that mediates cell-mediated immunity.T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effectorSpecific metabolic programs are tightly controlled to mediate T cell immune responses, and alterationsin T cell metabolism may result in many immunological disorders.in T cell metabolic programming during T cell homeostasis, differentiation, and function.
Keywords: T cell immunity metabolic pathways nutrient uptake metabolic checkpoints
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 227-239 doi: 10.1007/s11684-021-0896-8
Keywords: cannabidiol depression radial neural stem cells neurogenesis
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapyThe low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT).TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered Tinterferon-g and granzyme B production and in vitro cancer cellTCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized
Keywords: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Stem cell research in hepatocellular carcinoma
SUN Chengyi, ZUO Shi
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 1-4 doi: 10.1007/s11684-008-0001-6
Keywords: lineage hepato-pancreas differentiation block carcinogenesis current status
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma
Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 711-725 doi: 10.1007/s11684-020-0808-3
Keywords: chimeric antigen receptor T (CAR-T) cell lymphoma cytokine release syndrome (CRS) immune effector cell-associated
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 701-710 doi: 10.1007/s11684-020-0763-z
Keywords: acute myeloid leukemia CAR T immunotherapy
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 420-429 doi: 10.1007/s11684-016-0478-3
Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of componentsinvolved in the cell cycle machinery.Functional studies showed that ectopic expression of CDKN2C induced a cell cycle arrest at the G0/G1 phase and a partial differentiation in NB4 cells.progression and differentiation block of APL cells and may provide new insights into the study of pathogenesis
Keywords: CDKN2C acute promyelocytic leukemia cell cycle arrest differentiation
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 285-294 doi: 10.1007/s11684-021-0843-8
Keywords: CAR-T cell therapy refractory diffuse large B-cell lymphoma cytokine release syndrome dose-limiting
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 442-458 doi: 10.1007/s11684-021-0877-y
Keywords: T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination
Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 468-477 doi: 10.1007/s11684-015-0419-6
Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathologicalBone marrow (BM) infiltration is more commonly present in mature T-cell lymphoid malignancies comparedthis study, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cellThese included 29 cases of T-cell lymphoproliferative disorders (T-LPD, all with BM infiltration) and196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration
Keywords: mature T-cell lymphoid malignancies clonal T-cell population bone marrow infiltration prognostic factors
Nano thermo-hydrodynamics method for investigating cell membrane fluidity
YANG Yang, LIU Jing
Frontiers in Energy 2008, Volume 2, Issue 2, Pages 121-128 doi: 10.1007/s11708-008-0033-2
Keywords: responsible phenomenological phenomena modes–lateral diffusion differentiation
Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia
Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 416-420 doi: 10.1007/s11684-012-0224-4
Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acutephenotype that resembles early T-cell precursor, which confers a much poorer prognosis than any otherform of T-ALL.This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic
Keywords: acute lymphoblastic leukemia early T precursor prognosis
Monocyte subsets and their differentiation tendency after burn injury
Guangqing Wang, Zhaofan Xia
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 397-400 doi: 10.1007/s11684-013-0298-7
Monocytes are critical effectors and regulators of immune response. Studying the nomenclature of monocyte subsets may be beneficial for understanding the complex function of monocytes in steady and inflammatory states. A monocyte has the potential to differentiate into dendritic cells or macrophages, and this behavior significantly changes in severely burned patients and mice. The findings in the present study may help enhance understanding on the perturbation of the immune system after severe burn injury.
Keywords: monocyte differentiation burn
Title Author Date Type Operation
Deubiquitinases as pivotal regulators of T cell functions
Xiao-Dong Yang, Shao-Cong Sun
Journal Article
CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies
Journal Article
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
Journal Article
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
Journal Article
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma
Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang
Journal Article
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Journal Article
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang
Journal Article
Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse largeB-cell lymphoma in Chinese patients
Journal Article
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
Journal Article
Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies:
Wen Xue,Yan Sheng,Xiangqin Weng,Yongmei Zhu,Yan Zhao,Pengpeng Xu,Xiaochun Fei,Xiaoyan Chen,Li Wang,Weili Zhao
Journal Article
Nano thermo-hydrodynamics method for investigating cell membrane fluidity
YANG Yang, LIU Jing
Journal Article
Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia
Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen
Journal Article